CHAPTER 13: PERFECT DEFENSES (Part 2)

INFLAMM-AGING

Barbieri, Michelangela, et al. “Chronic Inflammation and the Effect of IGF-1 on Muscle Strength and Power in Older Persons.” Am J Physiol Endocrinol Metab 284 (2002): E481-487.

Capri, Miriam, et al. “The Genetics of Human Longevity.” Ann NY Acad Sci 1067 (2006): 252-63.

Franceschi, Claudio, et al. “Inflamm-aging.” Ann NY Acad Sci 908 (2000): 244-54.

Franceschi, Claudio, et al. “Genes Involved in Immune Response/Inflammation, IGF1/Insulin Pathway and Response to Oxidative Stress Play a Major Role in the Genetics of Human Longevity: The Lesson of Centenarians.” Mechanisms of Ageing and Development 126 (2005): 351-61.

Franceschi, Claudio, et al. “Inflammaging and Anti-Inflammaging: A Systemic Perspective on Aging and Longevity Emerged from Studies in Humans.” Mechanisms of Ageing and Development 128 (2007): 92-105.

Vasto, Sonya, and Et al. “Inflammatory Networks in Ageing, Age-Related Diseases and Longevity.” Mechanisms of Ageing and Development 128 (2007): 83-91.

THE SMOKING GUN

Anderson, Pauline. “New Findings Further Explain Strong Link Between Depression, Heart Disease, and Stroke.” 2009. 18 Feb. 2009<http://www.medscape.com/viewarticle/588400_print>.

“Aspirin May Lower Risk of Death in Older Women.” 26 Mar. 2007. 27 Mar. 2007 <http://online.wsj.com/article/SB11749265653149163.html>.

Barclay, Laurie, and Desiree Lie. “Elevated WBC Count May Be Associated with Increased Cancer Risk.” 24 Jan. 2006. 25 Jan. 2006<http://www.medscape.com/viewarticle/522146_print>.

Barclay, Laurie, and Desiree Lie. “Reducing Inflammation in Early Diabetes Preserves Function in Elderly Patients.” 29 Sept. 2006. 5 Oct. 2006 <http://www.medscape.com/viewarticle/545305_print>.

Barclay, Laurie, and HT Nghiem. “C-Reactive Protein Predicts Rapid Progression of Coronary Artery Disease.” 20 Sept. 2004. 21 Sept. 2004 <http://www.medscape.com/viewarticle/489592_print>.

Bakalar, Nicholas. “Patterns: Aspirin Linked to Lower Risk of Cancer and Heart Disease.” 19 June 2007. 19 June 2007<http://www.nytimes.com/2007/06/19/health/19patt.html>.

“Blood Proteins May Help Warn of Diabetes.” 27 Apr. 2004. 28 Apr. 2004 <http://www.msnbc.msn.com/id/4845335/>.

Boggs, Will. “Aspirin use linked to lower prostate cancer risk.” 12 Feb. 2004. 17 Feb. 2004 <http://www.medscape.com/viewarticle/469155_print>.

Capri, Miriam, et al. “The Genetics of Human Longevity.” Ann NY Acad Sci 1067 (2006): 252-63.

Carriere, Isabelle, et al. “Biomarkers of Inflammation and Malnutrition Associated with Early Death in Healthy Elderly People.” J Am Geriatr Soc 2008 (56): 840- 46.

Cassels, Caroline, and Penny Murata. “Long-term Use of Ibuprofen Lowers Alzheimer’s Disease Risk.” 8 May 2008. 10 May 2008<http://www.medscape.com/viewarticle/574190_print>.

Coussens, Lisa M., and Zena Werb. “Inflammation and cancer.” Nature 420 (2002): 860-67.

“C-Reactive Protein Level Linked to Outcome in Muscle-Invasive Bladder Cancer.” 2 May 2008. 6 May 2008 <http://www.medscape.com/viewarticle/573950_print>.

Chustecka, Zosia. “C-Reactive Protein Could Predict Prognosis in Advanced Prostate Cancer.” 26 Feb. 2007. 27 Feb. 2007<http://www.medscape.com/viewarticle/552744_print>.

D’Amore, Paula J. “Evolution of C-Reactive Protein as a Cardiac Risk Factor.” Lab Med 36 (2005): 234-38.

Danesh, John, etal. “Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count with Coronary Heart Disease.” JAMA 279 (1998): 1477-482.

Douglas, David. “Global Inflammation: a Cardiovascular Risk Marker for Women.” 28 Dec. 2005. 29 Dec. 2005 <http://www.medscape.com/viewarticle/520593_print>.

Dunham, Will. “Aspirin Seen Cutting Risk of Type of Breast Cancer.” 30 Apr. 2008. 1 May 2008 <http://www.reuters.com/article/idUSN3053699320080430>.

Elenkov, Ilia J., et al. “Cytokine Dysregulation, Inflammation and Well-Being.” Neuroimmunomodulation 12 (2005): 255-69.

Elias, Marilyn. “Study: Depression Can Exacerbate Heart Failure.” 13 Mar. 2008. 13 Mar. 2008 <http://www.usatoday.com/news/health/2008-03-11-depression-heart-failure_N.htm?loc=interstitialskip>.

Forrester, James S., and Justing Bick-Forrester. “Persistence of Inflammatory Cytokines Cause a Spectrum of Chronic Progressive Diseases: Implications for Therapy.” Med Hypotheses 65 (2005): 227-31.

Gale, Karla. “C-Reactive Protein Levels Point to Cardiovascular Risk.” 15 Dec. 2004. 16 Dec. 2004 <http://www.medscape.com/viewarticle/496117_print>.

Glurich, I., et al. “Systemic Inflammation in Cardiovascular and Periodontal Disease: A Comparative Study.” Clin Diagn Lab Immunol 9 (2002): 425-32.

Golden, Sherita Hill, et al. “Examining a Bidirectional Association Between Depressive Symptoms and Diabetes.” JAMA 299 (2008): 2751-759.

Grady, Denise. “Study Says Test May Surpass Cholesterol as Risk Marker.” New York Times 13 Nov. 2002.

“High C-Reactive Protein Levels Predict Onset of Hypertension.” 9 Dec. 2003. 10 Dec. 2003. http://www.medscape.com/viewarticle/465726_print

Hvilsom, Gitte B., et al. “C-Reactive Protein: A Serological Marker for Preterm Delivery.” Acta Obstet Gynecol Scand 81 (2002): 424-29.

“Inflammation’s Dual Role.” 9 Nov. 2004. 13 Mar. 2008 <http://www.usatoday.com/news/health/2004-11-09-inflammation_x.htm>.

Jeffrey, Susan. “Biomarkers Predict Prognosis, Recurrence After Ischemic Stroke.” 30 Oct. 2006. 31 Oct. 2006 <http://www.medscape.com/viewarticle/546836_print>.

Johnson, B. Delia, et al. “Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome in Women.” Circulation 109 (2004): 726-32.

Kop, WJ, et al. “Inflammation and coagulation factors in persons over 65 years of age with symptoms of depression but without evidence of myocardial ischemia.” Am J Cardiol 89 (2002): 419-24.

Kushner, Irving, Debra Rzewnicki, and David Samols. “What Does Minor Elevation of C-Reactive Protein Signify?” Am J Med 119 (2006): 166.e17-66.e28.

Ludwig, RJ, et al. “Psoriasis: A Possible Risk Factor for Development of Coronary Artery Calcification.” Br J Dermatol 156 (2007): 271-76.

Malemud, Charles J., and Mark E. Schulte. “Is There a Final Common Pathway for Arthritis?” Future Rheumatol 3 (2008): 253-68.

Mangiafico, Roberto A., et al. “Impaired Cognitive Performance in Asymptomatic Peripheral Arterial Disease: Relation to C-Reactive Protein and D-dimer Levels.” Age and Ageing 35 (2006): 60-65.

Meggs, William Joel, and Carol Svec. The Inflammation Cure. Chicago, Il: Contemporary Books, 2003.

Meyer, Michele. “Inflammation Emerges as a Marker to Detect Heart Attack Rish.” AARP Bulletin Online Oct. 2003.<http://www.aarp.org/bulletin/yourhealth/articles/a2003-10-15-revelations.html>.

Pai, Jennifer K., et al. “Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women.” N Engl J Med 351 (2004): 2599-610.

Parnell, Sean. “Aspirin Cuts Skin Cancer.” 5 Nov. 2005. 7 Nov. 2005 <http://www.theaustralian.news.com.au/printpage/0.5942,121611178,00.html>.

Pelsajovich, Andrea, et al. “C-reactive Protein at the Interface Between Innate Immunity and Inflammation.” Expert Rev Clin Immunol 4 (2008): 379-90.

Pickup, John C. “Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabetes.” Diabetes Care 27 (2004): 813-23.

Pietropaolo, Massimo, et al. “The Heterogeneity of Diabetes: Unraveling a Dispute: Is Systemic Inflammation Related to Islet Autoimmunity.” Diabetes 56 (2007):1189-197.

“Proteins Hold Clues to Chronic Pain”. 26 July 2006. 26 July 2006 <http://news.yahoo.com/s/hsn/20060726/hl_hsn/proteinsholdcluestochronicpain>.

Retterstol, L., et al. “C-reactive protein predicts death in patients with previous premature myocardial infarction-A 10 year follow-up study.” Atherosclerosis 160 (2002): 433-40.

Rifai, Nader, et al. “Is C-Reactive Protein Specific for Vascular Disease in Women?” Ann Intern Med 136 (2002): 529-33.

Ridker, Paul M. “C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women.” NEJM 342 (2000): 836-43.

Ridker, Paul M., et al. “Inflammation, Aspirin, and the risk of cardiovascular disease in apparently healthy men.” NEJM 336 (1997): 973-79.

Schram, MT, et al. “Vascular risk factors and markers of endothelial function as determinants of inflammatory markers in type 1 diabetes: the EURODIAB Prospective Complications Study.” Diabetes Care 26 (2003): 2165-73.

Stein, Rob. “Study: Aspirin Cuts Colon Cancer Risk.” Washington Post 6 Mar. 2003: A02.

Szabo, Liz. “Inflammation’s Dual Role.” USA Today 10 Nov. 2004.<http://www.usatoday.com/news/health/2004-11-09-inflammation_x.htm>.

Uceyler, Nurcan, et al. “Reduced Levels of Antiinflammatory Cytokines in Patients with Chronic Widespread Pain.” Arthritis and Rheumatism 54 (2006): 2656-664.

INFLAMMATORY BURDEN

Petersen, Bente K., and Mark A. Febbraio. “Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6.” Physiol Rev 88 (2008): 1379-406.

THE STORY CONDENSED

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