CHAPTER 15: PERFECT PUZZLE COMPLETED (Part 1)

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ANOTHER CORNER OF THE PUZZLE

Allen, Nioni E et al. “The Associations of Diet with Serum Insulin-like Growth Factor I and its Main Binding Proteins in 292 Women Meat-Eaters, Vegetarians, and Vegans.” Cancer Epidem Biomarkers Prev 11 (2002): 1441-448.

Calle, Eugenia E. and Rudolph Kaaks. “Overweight, Obesity and Cancer: Epidemiological Evidence and Proposed Mechanisms.” Nature Reviews 4 (2004): 579-91.

Campbell, T. Colin and Thomas M. Campbell II. The China Study. Dallas, TX: Benbella Books, 2005.

Chen, Chu et al. “Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-3 and the Risk of Fibrocystic Breast Conditions Among Chinese Women.” Int J Cancer 118 (2006): 2303-309.

Dewell, Antonella et al. “Relationship of Dietary Protein and Soy Isoflavones to Serum IGF-I and IGF Binding Proteins in the Prostate Cancer Lifestyle Trial.” Nutrition and Cancer 58 (2007): 35-42.

Fleming, Richard M. and Tom Monte. Stop Inflammation Now. New York: G.P. Putnam’s Sons, 2004.

Fontana, Luigi,et al. “Low Bone Mass in Subjects on a Long-term Raw Vegetarian Diet.” Arch Intern Med 165 (2005): 684-89.

Fontana, Luigi, Samuel Klein, and John O. Holloszy. “Long-term Low-protein, Low-calorie Diet and Endurance Exercise Modulate Metabolic Factors Associated with Cancer Risk.” Am J Clin Nutr 84 (2006): 1456-462.

Fontana, Luigi et al. “Long-Term Effects of Calorie or Protein Restriction on Serum IGF-1 and IGFBP-3 Concentration in Humans.” Aging Cell 7 (2008): 681-87.

Giovannucci, Edward et al. “Nutritional Predictors of Insulin-like Growth Factor I and Their Relationships to Cancer in Men.” Cancer Epidem Biomarkers Prev 12 (2003): 84- 89.

Grant, William B. “A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer Mortality.” European Urology 45 (2004): 271-79.

Heaney, Robert P. et al. “Dietary Changes Favorable Affect Bone Remodeling in Older Adults.” J Am Diet Assoc 1999 (99): 1228-233.

Holmes, Michelle D. et al. “Dietary Correlates of Plasma Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations.” Cancer Epidem Biomarkers Prev 11 (2002): 852-61.

Hoppe, C. et al. “High Intakes of Skimmed Milk, but not Meat, Increase Serum IGF-1 and IGFBP-3 in Eight-Year-Old Boys.” Eur J Clin Nutr 58 (2004): 1211-216.

Jenkins, Paul J. and Stephen A. Bustin. “Evidence for a Link between IGF-1 and Cancer.” Eur J Endocrinology 151 (2004): S17-22.

Larsson, Susanna C. et al. “Association of diet with serum insulin-like growth factor 1 in middle-aged and elderly men.” Am J Clin Nutr 81 (2005): 1163-167.

Linn, T. et al. “Effect of Long-Term Dietary Protein Intake on Glucose Metabolism in Humans.” Diabetologia 43 (2000): 1257-265.

McDougall, John. “Protein Overload.” The McDougall Newsletter (Jan. 2004).

McDougall, John. “Aging in Style.” The McDougall Newsletter (Jan. 2006).

McDougall, John. “When Friends Ask: “Why Don’t You Drink Milk?”” McDougall Newsletter (Mar. 2007).

Meat ‘Ups Prostate Cancer Risk’ 9 Oct. 2008 <http://news.bbc.co.uk/go/pr/fr/-/2/hl/health/7655405.stm>.

Melnik, BC. “Milk Consumption: Aggravating Factor of Acne and Promoter of Chronic Diseases of Western Society.” J Dtsch Dermatol Ges 7 (2009): 364-70.

Norat, T. et al. “Diet, Serum Insulin-Like Growth Factor-1 and IGF-Binding Protein-3 in European Women.” Eur J Clin Nutr 61 (2007): 91-98.

Pollak, Michael N. et al. “Insulin-Like Growth Factors and Neoplasia.” Nature Reviews Cancer 4 (2004): 505-18.

Rincon, Marielisa, Eric Rudin, and Nir Barzilai. “The Insulin/IGF-1 Signaling in Mammals and It’s Relevance to Human Longevity.” Eperimental Gerontology 40 (2005): 873-77.

Toniolo, Paolo et al. “Serum Insulin-Like Growth Factor-I and Breast Cancer.” Int J Cancer 88 (2000): 828-32.

Yu, Herbert and Thomas Rohan. “Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression.” J Natl Cancer Inst 92 (2000): 1472-489.

STIMULATING CANCER CELLS AND OTHER UNWISE PURSUITS

Allen, NE et al. “Hormones and Diet: Low Insulin-Like Growth Factor-1 but Normal Bioavailable Androgens in Vegan Men.” Brit J Cancer 83 (2000): 95-97.

Allen, Nioni E. et al. “The Associations of Diet with Serum Insulin-like Growth Factor I and its Main Binding Proteins in 292 Women Meat-Eaters, Vegetarians, and Vegans.” Cancer Epidem Biomarkers Prev 11 (2002): 1441-448.

Balkwill, Fran and Alberto Mantovani. “Inflammation and Cancer: Back to Virchow?” Lancet 357 (2001): 539-45.

Calle, Eugenia E., and Rudolph Kaaks. “Overweight, Obesity and Cancer: Epidemiological Evidence and Proposed Mechanisms.” Nature Reviews 4 (2004): 579-91.

Campbell, T. Colin and Thomas M. Campbell II. The China Study. Dallas, TX: Benbella Books, 2005.

Chen, Chu et al. “Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-3 and the Risk of Fibrocystic Breast Conditions Among Chinese Women.” Int J Cancer 118 (2006): 2303-309.

Cotran, Ramzi, Vinay Kumar, and Tucker Collins. Pathologic Basis of Disease, Sixth Edition. W.B. Saunders Company, 1999.

Coussens, Lisa M. and Zena Werb. “Inflammation and cancer.” Nature 420 (2002): 860-67.

Dawson-Hughes, Bess, Susan S. Harris, and Lisa Ceglia. “Alkaline Diets Favor Lean Tissue Mass in Older Adults.” Am J Clin Nutr 87 (2008): 662-65.

Fleming, Richard M. and Tom Monte. Stop Inflammation Now. New York: G.P. Putnam’s Sons, 2004.

Fontana, Luigi, Samuel Klein, and John O. Holloszy. “Long-term Low-protein, Low-calorie Diet and Endurance Exercise Modulate Metabolic Factors Associated with Cancer Risk.” Am J Clin Nutr 84 (2006): 1456-462.

Fontana, Luigi et al. “Long-Term Effects of Calorie or Protein Restriction on Serum IGF-1 and IGFBP-3 Concentration in Humans.” Aging Cell 7 (2008): 681-87.

Grant, William B. “A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer Mortality.” European Urology 45 (2004): 271-79.

Holmes, Michelle D. et al. “Dietary Correlates of Plasma Insulin-like Growth Factor I and Insulin-like Growth Factor Binding Protein 3 Concentrations.” Cancer Epidem Biomarkers Prev 11 (2002): 852-61.

Hoppe, C. et al. “High Intakes of Skimmed Milk, but not Meat, Increase Serum IGF-1 and IGFBP-3 in Eight-Year-Old Boys.” Eur J Clin Nutr 58 (2004): 1211-216.

Jenkins, Paul J. and Stephen A. Bustin. “Evidence for a Link between IGF-1 and Cancer.” Eur J Endocrinology 151 (2004): S17-22.

Khan, Naghma et al. “Apoptosis by Dietary Factors: The Suicide Solution for Delaying Cancer Growth.” Carcinogenesis (2006). <advanced online publication>.

King, Christopher. “Cell (biology).” Microsoft Encarta Online Encyclopedia 2005. 2005. 15 Mar. 2006 <http://encarta.msn.com/text_761568585__1/Cell_(biology).html>.

Kundu, Joydeb Kumar and Surh Young-Joon. “Inflammation: Gearing the Journey to Cancer.” Mutation Research 659 (2008): 15-30.

Larsson, Susanna C. et al. “Association of diet with serum insulin-like growth factor 1 in middle-aged and elderly men.” Am J Clin Nutr 81 (2005): 1163-167.

Ma, Jing et al. “Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3.” J Natl Cancer Inst 91 (1999): 620-25.

McDougall, John. “Aging in Style.” The McDougall Newsletter (Jan. 2006).

Meat ‘Ups Prostate Cancer Risk’ 9 Oct. 2008 <http://news.bbc.co.uk/go/pr/fr/-/2/hl/health/7655405.stm>.

Meggs, William Joel and Carol Svec. The Inflammation Cure. Chicago, Il: Contemporary Books, 2003.

Melnik, BC. “Milk Consumption: Aggravating Factor of Acne and Promoter of Chronic Diseases of Western Society.” J Dtsch Dermatol Ges 7 (2009): 364-70.

Pan, Min-Hsiung et al. “Modulation of Inflammatory Genes by Natural Dietary Bioactive Compounds.” J Agric Food Chem. 57 (2009): 4467-477.

Pollak, Michael N. et al. “Insulin-Like Growth Factors and Neoplasia.” Nature Reviews Cancer 4 (2004): 505-18.

Roddam, Andrew W. et al. “Insulin-Like Growth Factors, Their Binding Proteins, and Prostate Cancer Risk: Analysis of Individual Patient Data from 12 Prospective Studies.” Ann Intern Med 149 (2008): 461-71.

Samaras, Thomas T., Harold Elrick, and Lowell H. Storms. “Is Height Related to Longevity?” Life Sciences 72 (2003): 1781-802.

Siemes, Claire et al. “C-Reactive Protein Levels, Variation in the C-Reative Protein Gene, and Cancer Risk: The Rotterdam Study.” J Clin Oncol 24 (2006): 5216-222.

Stein, Rob. “Body’s First Defense May be Root of Diseases.” Washington Post 16 Feb. 2003: A01.

Szabo, Liz. “Inflammation’s Dual Role.” USA Today 10 Nov. 2004. <http://www.usatoday.com/news/health/2004-11-09-inflammation_x.htm>.

Toniolo, Paolo et al. “Serum Insulin-Like Growth Factor-I and Breast Cancer.” Int J Cancer 88 (2000): 828-32.

World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. Rep. Washington DC: AICR, 2007.

Yu, Herbert and Thomas Rohan. “Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression.” J Natl Cancer Inst 92 (2000): 1472-489.

THE RIGHT AMOUNT OF IGF-1

Bailey, James L. and Harold A. Franch. “Getting to the Meat of the Matter: Beyond Protein Supplementation in Maintenance Dialysis.” Semin Dial Doi: 10.1111/j.1525- 139x.2009.00611.x (2009) epub ahead of print.

Barbieri, Michelangela et al. “Chronic Inflammation and the Effect of IGF-1 on Muscle Strength and Power in Older Persons.” Am J Physiol Endocrinol Metab 284 (2002): E481-487.

Barbieri, Michelangela et al. “Insulin/IGF-1-Signaling Pathway: An Evolutionarily Conserved Mechanism of Longevity from Yeast to Humans.” Am J Physiol Endocrinol Metab 285 (2003): E`064-1071.

Barnes, P, and BR Celli. “Systemic Manifestations and Comorbidities of COPD.” Eur Respir J 33 (2009): 1165-185.

Cappola, Anne R. et al. “Insulin-Like Growth Factor I and Interleukin-6 Contribute Synergistically to Disability and Mortality in Older Women.” J Clin Endocrinol Metab 88 (2003): 2019-025.

Capri, Miriam et al. “The Genetics of Human Longevity.” Ann NY Acad Sci 1067 (2006): 252-63.

Dewell, Antonella et al. “Relationship of Dietary Protein and Soy Isoflavones to Serum IGF-I and IGF Binding Proteins in the Prostate Cancer Lifestyle Trial.” Nutrition and Cancer 58 (2007): 35-42.

Durham, WJ. “Inflammatory Burden and Amino Acid Metabolism in Cancer Cachexia.” Curr Opin Clin Nutr Metab Care 12 (2009): 72-77.

Fearon, Kenneth C., Anne C. Voss, and Deborah S. Hustead. “Definition of Cancer Cachexia: Effect of Weight Loss, Reduced Food Intake, and Systemic Inflammation on Functional Status and Prognosis.” Am J Clin Nutr 83 (2006): 1345-350.

Fleming, Richard M and Tom Monte. Stop Inflammation Now. New York: G.P. Putnam’s Sons, 2004.

Franceschi, Claudio et al. “Genes Involved in Immune Response/Inflammation, IGF1/Insulin Pathway and Response to Oxidative Stress Play a Major Role in the Genetics of Human Longevity: The Lesson of Centenarians.” Mechanisms of Ageing and Development 126 (2005): 351-61.

Giovannucci, Edward et al. “Nutritional Predictors of Insulin-like Growth Factor I and Their Relationships to Cancer in Men.” Cancer Epidem Biomarkers Prev 12 (2003): 84- 89.

Holt, PG et al. “The role of allergy in the development of asthma.” Nature 402 suppl (1999): B12-17.

Institute of Medicine. The Role of Protein and Amino Acids in Sustaining and Enhancing Performance. Rep. Washington ,DC: National Academy P, 1999.

Libby, Peter. “Inflammation in Atherosclerosis.” Nature 420 (2002): 868-74.

Lira, Fabio S. et al. “Regulation of Inflammation in the Adipose Tissue in Cancer Cachexia: The Effect of Exercise.” Cell Biochem Funct 27 (2009): 71-75.

McDougall, John. “Aging in Style.” The McDougall Newsletter (Jan. 2006).

Melmed, Shlomo. “Supplemental Growth Hormone in Healthy Adults: The Endocrinologist’s Responsibility.” 20 Apr. 2006. 25 Apr. 2006 <http://www.medscape.com/viewarticle/529297_print>.

Melnik, BC. “Milk-The Promoter of Chronic Western Diseases.” Med Hypotheses 72 (2009): 631-39.

Pedersen, Bente K. and Mark A. Febbraio. “Muscle as an Endocrine Organ: Focus on Muscle- Derived Interleukin-6.” Physiol Rev 88 (2008): 1379-406.

Pirlich, Matthias et al. “Role of Intestinal Function in Cachexia.” Curr Opin Clin Nutr Metab Care 9 (2006): 603-06.

Pollak, Michael N. et al. “Insulin-Like Growth Factors and Neoplasia.” Nature Reviews Cancer 4 (2004): 505-18.

Sandek, Anja et al. “The Emerging Role of the Gut in Chronic Heart Failure.” Curr Opin Clin Nutr Metab Care 11 (2008): 632-39.

Sevenoaks, Martin J. and Robert A. Stockley. “Chronic Obstructive Pulmonary Disease, Inflammation and Co-Morbidity – A Common Inflammatory Phenotype.” Respiratory Research 7 (2006): 70.

Yu, Herbert and Thomas Rohan. “Role of the Insulin-Like Growth Factor Family in CancerDevelopment and Progression.” J Natl Cancer Inst 92 (2000): 1472-489.

TURN IT AROUND!

Allen, NE et al. “Hormones and Diet: Low Insulin-Like Growth Factor-1 but Normal Bioavailable Androgens in Vegan Men.” Brit J Cancer 83 (2000): 95-97.

Allen, Nioni E. et al. “The Associations of Diet with Serum Insulin-like Growth Factor I and its Main Binding Proteins in 292 Women Meat-Eaters, Vegetarians, and Vegans.” Cancer Epidem Biomarkers Prev 11 (2002): 1441-448.

Dawson-Hughes, Bess, Susan S. Harris, and Lisa Ceglia. “Alkaline Diets Favor Lean Tissue Mass in Older Adults.” Am J Clin Nutr 87 (2008): 662-65.

Fleming, Richard M. and Tom Monte. Stop Inflammation Now. New York: G.P. Putnam’s Sons, 2004.

Khan, Naghma, Farrukh Afaq, and Hasan Mukhtar. “Apoptosis by Dietary Factors: The Suicide Solution for Delaying Cancer Growth.” Carcinogenesis (2006). <advanced online publication>.

Norat, T.et al. “Diet, Serum Insulin-Like Growth Factor-1 and IGF-Binding Protein-3 in European Women.” Eur J Clin Nutr 61 (2007): 91-98.

INSULIN: A FRESH PATH TO UNDERSTANDING

Barclay, Laurie and Desiree Lie. “Different Proteins May Have Varying Insulinotropic Properties.” 17 Nov. 2004. 18 Nov. 2004<http://www.medscape.com/viewarticle/494021>.

Berkow, Susan E. and Neal Barnard. “Vegetarian Diets and Weight Status.” Nutrition Reviews 64 (2006): 175-88.

Dewell, Antonella et al. “Relationship of Dietary Protein and Soy Isoflavones to Serum IGF-I and IGF Binding Proteins in the Prostate Cancer Lifestyle Trial.” Nutrition and Cancer 58 (2007): 35-42.

Fleming, Richard M and Tom Monte. Stop Inflammation Now. New York: G.P. Putnam’s Sons, 2004.

Fraser, Gary E. Diet, Life Expectancy, and Chronic Disease: Studies of Seventh-day Adventists and Other Vegetarians. New York: Oxford UP, 2003.

Fuhrman, Joel. Eat to Live. Boston: Little, Brown and Company, 2003.

Linn, T.et al. “Effect of Long-Term Dietary Protein Intake on Glucose Metabolism in Humans.” Diabetologia 43 (2000): 1257-265.

McCarty, MF. “The Origins of Western Obesity: A Role for Animal Protein?” Med Hypotheses 64 (2000): 499-94.

Mohanty, Priya et al. “Both Lipid and Protein Intakes Stimulate Increased Generation of Reactive Oxygen Species by Polymorphonuclear Leukocytes and Mononuclear Cells.” Am J Clin Nutr 75 (2002): 767-72.

Pert, Candace B. Molecules of Emotion. New York: Scribner, 1997.

Rincon, Marielisa, Eric Rudin, and Nir Barzilai. “The Insulin/IGF-1 Signaling in Mammals and It’s Relevance to Human Longevity.” Experimental Gerontology 40 (2005): 873-77.

Waugh, Anne and Allison Grant. Anatomy and Physiology in Health and Illness. 9th ed. Churchill Livingstone, 2001.

MORE SUPPORTING PLAYERS

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